Download the Startup Crash Fix from Nexus Mods to patch the executable for modern processors.
Try running the game in Windowed Mode or use a "Borderless Window" tool if the game crashes when Alt-Tabbing or during cinematic-to-dialogue transitions. Known Game Glitches Left dialogue crashes - Deus Ex: Human Revolution Deus ex human revolution dialogue crash fix
Alternatively, use Process Lasso to restrict the game to fewer cores (e.g., 4 or 8) to prevent engine overflows. Download the Startup Crash Fix from Nexus Mods
Open and navigate to HKEY_CURRENT_USER\Software\Eidos\Deus Ex: HRDC (or Deus Ex: HR for the standard version). Find AllowJobStealing and set it to 0 . Deus ex human revolution dialogue crash fix