: Meredith Grey reaches a career pinnacle by pioneering a revolutionary abdominal wall transplant, which leads to her winning the prestigious Harper Avery Award .

: Amelia Shepherd discovers she has a massive, 10-centimeter benign brain tumor that has been influencing her erratic behavior for years.

: Jo Wilson finally confronts her abusive husband, Paul Stadler, when he arrives at the hospital, leading to a tense storyline that eventually results in his death and Jo's freedom. Major Cast Changes Season 14 saw a significant shake-up in the regular cast: Season 14 (Grey's Anatomy)