Quabain -

: This sodium buildup forces the cell to retain more calcium. In heart muscle cells, this extra calcium strengthens contractions.

: Conversely, abnormally high levels of endogenous ouabain are linked to chronic high blood pressure and heart failure. QUABAIN

(pronounced WAH-bane ), also known as g-strophanthin , is a potent cardiac glycoside and steroid hormone naturally found in both African plants and mammals. Historically used by African hunters as an arrow poison due to its rapid effect on the heart, it is now primarily used as a research tool for studying cell signaling and, in some countries, as a medication for heart conditions. How it Works: The Na+/K+-ATPase Pump : This sodium buildup forces the cell to retain more calcium

While once thought to be exclusively plant-based, scientists discovered that humans and other mammals produce an version of ouabain. (pronounced WAH-bane ), also known as g-strophanthin ,

: Produced in the adrenal glands and hypothalamus, it circulates in the blood at very low levels. Levels naturally rise during physical exercise or times of high salt intake. Modern Research & Potential Uses