[s1e22] Stronger, Faster -

The substance makes Ratchet highly effective in battle, but he becomes verbally abusive toward his teammates and excessively violent toward Decepticon miners.

Overconfident, Ratchet tracks down Megatron alone at a Decepticon energon mine. Despite his enhanced state, he is eventually overpowered and severely injured by Megatron. [S1E22] Stronger, Faster

Stronger, Faster – Transformers: Prime (Season 1, Episode 22) The substance makes Ratchet highly effective in battle,