Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats:
Ever wonder how your cells manage to survive, remodel tissue, or even respond to injury? Meet —one of the most versatile enzymes in the human body. Often referred to as tissue transglutaminase, TG2 is
TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing. Often referred to as tissue transglutaminase
Because TG2 is implicated in chronic conditions like cancer and neurodegeneration (such as Huntington's and Alzheimer's), it is now a hot target for new therapeutic drugs designed to selectively inhibit its activity without harming healthy cells. TG2 is a multifunctional